Caverject 20 Micrograms Powder For Solution For Injection

Treatment of priapism should not be delayed more than 6 hours. Alprostadil should not be used in patients who have a known hypersensitivity to alprostadil or to any of the excipients listed in section 6. Haemorrhage, Injection site haemorrhage, Inflammation, Caverjet site inflammation, Injection site warmth, Injection site oedema, Injection site swelling, Injection site pain, Injection site irritation, Asthenia, Injection site cavfrjet, Oedema, Oedema peripheral, Injection site pruritus. Doses of greater than 60 micrograms of alprostadil are not recommended. Therefore, a more consistent product delivery cavegjet produced when Bacteriostatic Water for Injection containing benzyl alcohol is used. Any alprostadil entering the systemic circulation from the corpus cavernosum will be rapidly metabolised, caverjet. Cavejret the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caution is advised when this option is exercised. No formal studies with Caverject have been performed in patients younger than 18 years and older than 75 years. Musculoskeletal and connective tissue disorders. Sympathomimetics may reduce the effect of alprostadil. Continue typing to refine. Withdraw cavdrjet more than the required dose caverjet Caverject caverje, remove the 22 gauge needle, and fit the 30 gauge needle, caverjet. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. In some patients, injection of alprostadil can induce a small amount of bleeding at the site of injection. As an aid to caverjet diagnosis. Each 1ml of reconstituted solution contains 8. The initial dose of alprostadil caverjet patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1.

Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. Holding the device upright, press the plunger rod as far as caverjeg will go. Reproductive System and Caverjet Disorders. High doses caverjet alprostadil 0. Enter medicine name or company Start typing to retrieve search suggestions. This site uses cookies. The minimum amount of benzyl alcohol at which toxicity may occur is not known, caverjet. Date of revision of the text. The treatment of priapism prolonged erection should not be delayed more than 6 hours. Caverject is indicated for the treatment of erectile dysfunction caverjet adult males due to caverjdt, vasculogenic, psychogenic or mixed aetiology. Premature and low-birth weight infants may be more likely to develop toxicity. Caverject uses a superfine needle for administration. Using aseptic technique, insert a gauge butterfly needle into the corpus cavernosum and aspirate ml of blood. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms. Caveruet view the changes to a medicine you must sign up and log in. Intracavernosal alprostadil was effective, acceptable, and generally well tolerated in men with arteriogenic erectile dysfunction. Urethral haemorrhage, Haematuria, Dysuria, Pollakiuria, Micturition urgency. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. The initial injections of Caverject Dual Chamber must be administered by medically trained personnel and after proper training, alprostadil may be injected at home. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs of penile fibrosis or Peyronie's disease. If the duration is longer, the dose should be reduced. Back to top Pfizer Limited contact details. Regular follow-up of patients, with careful examination of the penis, is strongly recommended to detect signs caverjet penile fibrosis or Peyronie's disease.

Sign Up Log In Cancel. If necessary, this may be followed by further aspiration of blood through the same caverjt needle. Company contact details Pfizer Limited. To bookmark a medicine you must sign up and log in. Subjects with evidence of neurological dysfunction: Caverject is not intended to be mixed or coadministered with any other products. By continuing to browse the site you are agreeing to our policy cvaerjet the use of cookies. Patients on anticoagulants such as warfarin or heparin may have increased propensity for bleeding after the intracavernosal injection. Sympathomimetics may reduce the effect of alprostadil. The first injections of alprostadil must be done by medically trained personnel, caverjet. Sodium For caverjet full list of excipients, see section 6. This information is intended for use by health professionals, caverjet. The minimum amount of benzyl alcohol at which toxicity may caverjet is not known. Overdosage was not observed in clinical trials with alprostadil. Haemorrhage, Injection site haemorrhage, Inflammation, Injection site inflammation, Injection site warmth, Injection site oedema, Injection site swelling, Injection site pain, Injection site irritation, Asthenia, Injection site anaesthesia, Oedema, Oedema peripheral, Injection site pruritus. The solution should be clear. Show table caverjet contents Hide table of contents 1. In the majority of the cases, caverjet pain caverjet rated mild or moderate in intensity. A few drops will appear at the needle tip. Although the usual contra-indication to intrapenile administration of a vasoconstrictor caverjet not apply in the treatment of priapism, caution is advised when this option is exercised.

This may detumesce the penis. The adverse drug reactions are listed in order cacerjet decreasing medical seriousness within each frequency category and system organ class. Patients should be instructed to report to a physician any erection lasting for a prolonged time period, such as 4 hours cavrejet longer. Therefore, a more consistent product delivery is produced when Bacteriostatic Water for Injection xaverjet benzyl alcohol is used. Alprostadil should be used with caution in patients who have experienced transient ischaemic attacks or those with unstable cardiovascular disorders. A half inch, 27 to 30 gauge needle is caverjet recommended. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent caverjet. Remove the outer protective cap of the needle. Medically reviewed on Feb 6, Predisposition to priapism eg, sickle cell anemia or cavrjet, multiple myeloma, leukemia. The pharmacologic effect of alprostadil in the treatment of erectile dysfunction is presumed caverjet be mediated by inhibition of alpha 1 -adrenergic activity in penile tissue and by its relaxing effect on cavernosal smooth muscle, caverjet. The potential for abuse of alprostadil should be considered in patients with a history of psychiatric disorder or addiction. Patients should be instructed to report immediately to a physician, or if unavailable caverjrt seek immediate medical assistance for any erection lasting for a prolonged time period, such as 4 hours. Dosage Information in more detail. Apart cvaerjet the starting dose, it is possible to dose titrate with either Caverject Dual Chamber or Caverject Powder for Injection with similar caverjet to the treatment of non-neurogenic erectile dysfunction. Also impotence has reportedly been caused by 16 of the most commonly caverjey drugs, including drugs for high caverjet pressure, heart disease, and depression. If there is no response to the administered dose, then the next higher dose may be given within one hour. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors.

Caverjet

Other side effects include bleeding at the injection site and an unhealthy, prolonged erection of four to six hours. The effects of combinations of alprostadil with other treatments for erectile dysfunction e. Single pack containing a 5 ml clear, caverjet, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and cavejret aluminium overseal with polypropylene flip-off cap. The second dose should be 5 micrograms if there is a partial response, and 7. Treatment with alprostadil should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Cavejret disease. The cagerjet signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. This may detumesce the penis. Extreme caution is required in patients with coronary heart disease, uncontrolled hypertension, caverjet ischaemia, and in subjects taking monoamine oxidase inhibitors. Musculoskeletal and connective tissue disorders. Musculoskeletal and Connective Tissue Disorders. Doses of greater than 60 micrograms of alprostadil are not recommended. Find out more here. It is recommended that the dose administered produces a caverjwt of the erection not exceeding one hour. In some patients, injection of alprostadil can induce a small amount of bleeding at the site of injection. Use immediately after cavegjet. Although the usual contra-indication to intrapenile administration caverjet a vasoconstrictor does not apply in the treatment of priapism, caution is advised when this option is exercised. If still unsuccessful, intracavernous injection of alpha-adrenergic medication is recommended. Patient must not adjust cavejret on own. The maximum dose of phenylephrine should be 1 mg, or adrenaline micrograms caverjet ml of the solution. Concomitant with anticoagulants may increase inj site bleeding. Last updated on eMC: Inject the 1 ml of diluent into the vial, and shake to dissolve the powder entirely.

Although the usual contra-indication to intrapenile administration of a vasoconstrictor does not apply in the treatment of priapism, caution is cavermet when this option is exercised. The adverse drug reactions are caverjst in order of decreasing medical seriousness within each frequency category and system organ class. If there is no response to the administered caverjet, then the next higher dose may be given within one hour. Alprostadil should be used with caution caverjet patients with cardiovascular and cerebrovascular risk factors. Extreme csverjet is required in patients with coronary heart disease, caverjet, uncontrolled hypertension, cerebral ischaemia, and in subjects taking monoamine oxidase inhibitors. Inject the 1 ml of diluent caverjet the cavrrjet, and shake to dissolve the powder entirely. Following intracavernous injection of 20 micrograms of alprostadil, mean peripheral levels of alprostadil at 30 and 60 minutes after injection are not significantly greater than baseline levels of endogenous PGE 1. Alprostadil should cavermet used with caverjet in patients who have caveret transient ischaemic attacks or those with unstable cardiovascular disorders. The dose that is selected for self-injection treatment should provide the patient with an erection that is satisfactory for sexual intercourse. By continuing to browse the site you are agreeing caferjet our policy on the use of cookies. Last updated on eMC: In patients infected with blood-borne diseases, this could increase the transmission of caverjet diseases to their partner. To minimize the risk, select the lowest effective dose. Caverject Dual Chamber powder: Caverjet The initial dose of alprostadil in patients with erectile dysfunction of neurogenic origin secondary to spinal cord injury is 1. Both the side of the penis that is injected and the site of injection must be alternated; prior to the injection, the injection site must be cleansed with an alcohol swab. Alprostadil did not affect rat spermatogenesis at doses times greater than the proposed human intrapenile dose. Sexual stimulation and intercourse can lead to cardiac and pulmonary events in patients with coronary heart disease, congestive heart failure or pulmonary disease. Reporting of suspected adverse reactions Reporting suspected adverse caverjett after authorisation of the medicinal product caverjet important. To minimize the risk, select the lowest effective dose. Powder for solution for injection A white to off-white powder. No caverjet information additional to that already contained in this SPC.

caverjet

Show table of contents Hide table of contents 1. No relevant information additional to that already contained in this SPC. Alprostadil at subcutaneous doses of up to 0. Reevaluate every 3 months. Treatment with alprostadil should be discontinued in patients who develop penile angulation, cavernosal fibrosis, or Peyronie's disease. Underlying treatable medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of therapy with alprostadil. The pharmacotoxic signs of alprostadil are similar in all animal species and include depression, soft stools or diarrhoea and rapid breathing. Single pack containing a 5 ml clear, colourless, glass vial of Caverject 20 micrograms powder with a bromobutyl rubber stopper and an aluminium overseal with polypropylene flip-off cap. Duplex ultrasonography was used to measure the peak systolic velocity and diameter of the cavernosal arteries at the end of the titration phase and after 4, 8, and 12 months of the home phase. The site of injection is usually along the dorsolateral aspect of the proximal third of the penis. If necessary, this may be followed by further aspiration of blood through the same butterfly needle. Show table of contents Hide table of contents 1. Caverject may be a useful adjunct to other diagnostic tests in the diagnosis of erectile dysfunction. The most frequent adverse reaction after intracavernosal injection of alprostadil is penile pain. Blood pressure and pulse should be continuously monitored during the procedure. Alprostadil is present in various mammalian tissues and fluids. They should remove the needle from the syringe, discard it, and attach a new, unused sterile needle to the syringe. Refer to our editorial policy for content sources and attributions. Painful erection is more likely to occur in patients with anatomical deformations of the penis, such as angulation, phimosis, cavernosal fibrosis, Peyronie's disease or plaques. Back to top Pfizer Limited contact details. The initial dose of alprostadil for erectile dysfunction of vasculogenic, psychogenic, or mixed aetiology is 2. Alprostadil 20mcg, 40mcg; per vial; lyophilized pwd for intracavernous inj after reconstitution; contains benzyl alcohol. Alprostadil cagerjet not intended for co-administration with any other agent for the treatment of erectile dysfunction see Section 4. Blood creatinine increased, Blood pressure decreased, Heart rate increased. Fit caverjet 22 gauge needle to the syringe.

Read all information given to you. Underlying treatable medical causes of erectile dysfunction should be diagnosed and treated prior to initiation of therapy with alprostadil. The maximum dose of phenylephrine should be 1 mg, or adrenaline micrograms 5 ml of the solution. Needle breakage, with a portion of the needle remaining in the penis, has been reported and, in some cases, required hospitalisation and surgical removal. Adjust volume to the required dose for injection. The patient should be instructed that, if the needle is bent, it must not be used; they should also not attempt to straighten a bent needle. Haemorrhage, Injection site haemorrhage, Inflammation, Injection site inflammation, Injection site warmth, Injection site oedema, Injection site swelling, Injection site pain, Injection site irritation, Asthenia, Injection site anaesthesia, Oedema, Oedema peripheral, Injection site pruritus. This information is intended for use by health professionals. If there is no response to the administered dose, then the next higher dose may be given within 1 hour. Qualitative and quantitative composition 3. Caverject should be used with caution in patients with cardiovascular and cerebrovascular risk factors. Caverject Dual Chamber powder:. Although the pharmacokinetics of alprostadil have not been formally examined in patients with renal or hepatic insufficiency, alterations in renal or hepatic function would not be expected to have a major influence on the pharmacokinetics of alprostadil. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at www. Subjects without evidence of neurological dysfunction: In some patients, injection of alprostadil can induce a small amount of bleeding at the site of injection. To reconstitute Caverject using the prefilled diluent syringe: Continue typing to refine. If the duration is longer, the dose should be reduced. The presence of benzyl alcohol in the reconstitution vehicle decreases the degree of binding to package surfaces. Reconstituted solutions should be used immediately and not stored. Fit the 22 gauge needle to the syringe. The majority of patients achieve a satisfactory response with doses in the range of 5 to 20 micrograms, caverjet. Blood pressure and pulse should be continuously monitored during the procedure. Caverject uses a superfine needle for administration. Following administration, any unused contents of the vial or syringe should be discarded. The daverjet injections of Caverject Caverjet Chamber must be administered by medically trained personnel and after proper training, alprostadil may be injected at home.

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